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ISBN: 9781265979317
Editorial: McGrawHill
Autor: Longo . Fauci . Kasper . Hauser
Edición: 22ª - 2025
Idioma: Inglés
Impresión: Color
Páginas: 4400
Formato:
Alto: 28 cm
Ancho: 22 cm
Encuadernación: Tapa Dura
The acclaimed, landmark guide to internal medicine—updated to reflect the latest guidelines and recommendations.
The Voice of Clinical Reason
For more than seven decades, Harrison’s Principles of Internal Medicine has provided healthcare professionals with the informational foundation needed to provide optimal patient care. The world’s leading authority on applied pathophysiology and clinical medicine, this trusted resource has covered countless advances and developments across the full span of medicine.
Fully updated, the new 22nd edition has been modified extensively in its structure and content and offers a standardized format for each disease chapter. The authors and editors have curated and synthesized the vast amount of information that comprises general internal medicine and each of the major specialties into a highly readable and informative resource.
Harrison’s is world-renowned as the most authoritative source for:
This twenty-second edition features:
CONTENTS:
Part 1: The Profession of Medicine
Chapter 1: The Practice of Medicine
Chapter 2: Promoting Good Health
Chapter 3: Vaccine Opposition and Hesitancy
Chapter 4: Decision-Making in Clinical Medicine
Chapter 5: Precision Medicine and Clinical Care
Chapter 6: Screening and Prevention of Disease
Chapter 7: The Safety and Quality of Health Care
Chapter 8: The Value of the Physical Examination in Modern Medicine
Chapter 9: Physician Well-Being
Chapter 10: Diagnosis: Reducing Errors and Improving Quality
Chapter 11: Racial and Ethnic Disparities in Health Care
Chapter 12: Ethical Issues in Clinical Medicine
Chapter 13: Palliative and End-of-Life Care
Part 2: Cardinal Manifestations and Presentation of Diseases
Section 1: Pain
Updated! Chapter 14: Pain: Pathophysiology and Management
Chapter 15: Chest Discomfort
Chapter 16: Abdominal Pain
Chapter 17: Headache
Chapter 18: Low Back Pain
Chapter 19: Neck Pain
Section 2: Alterations in Body Temperature
Chapter 20: Fever
Chapter 21: Fever and Rash
Chapter 22: Fever of Unknown Origin
Section 3: Nervous System Dysfunction
Chapter 23: Syncope
Chapter 24: Dizziness and Vertigo
Chapter 25: Fatigue
Chapter 26: Neurologic Causes of Weakness and Paralysis
Chapter 27: Numbness, Tingling, and Sensory Loss
Chapter 28: Gait Disorders, Imbalance, and Falls
Chapter 29: Confusion and Delirium
Chapter 30: Coma
Chapter 31: Dementia
Chapter 32: Aphasia, Memory Loss, and Other Cognitive Disorders
Chapter 33: Sleep Disorders
Section 4: Disorders of Eyes, Ears, Nose, and Throat
Chapter 34: Disorders of the Eye
Chapter 35: Disorders of Smell and Taste
Chapter 36: Disorders of Hearing
Chapter 37: Upper Respiratory Symptoms, Including Earache, Sinus Symptoms, and Sore Throat
Chapter 38: Oral Manifestations of Disease
Section 5: Alterations in Circulatory and Respiratory Functions
Chapter 39: Dyspnea
Chapter 40: Cough
Chapter 41: Hemoptysis
Chapter 42: Hypoxia and Cyanosis
Chapter 43: Edema
Chapter 44: Approach to the Patient with a Heart Murmur
Chapter 45: Palpitations
Chapter 46: Exercise Intolerance
Section 6: Alterations in Gastrointestinal Function
Chapter 47: Dysphagia
Chapter 48: Nausea, Vomiting, and Indigestion
Chapter 49: Diarrhea and Constipation
Chapter 50: Unintentional Weight Loss
Chapter 51: Gastrointestinal Bleeding
Chapter 52: Jaundice
Chapter 53: Abdominal Swelling and Ascites
Section 7: Alterations in Renal and Urinary Tract Function
Chapter 54: Interstitial Cystitis/Bladder Pain Syndrome
Chapter 55: Azotemia and Urinary Abnormalities
Chapter 56: Fluid and Electrolyte Disturbances
Chapter 57: Hypercalcemia and Hypocalcemia
Chapter 58: Acidosis and Alkalosis
Section 8: Alterations in the Skin
Chapter 59: Approach to the Patient with a Skin Disorder
Chapter 60: Eczema, Psoriasis, Cutaneous Infections, Acne, and Other Common Skin Disorders
Chapter 61: Skin Manifestations of Internal Disease
Chapter 62: Immunologically Mediated Skin Diseases
Chapter 63: Cutaneous Drug Reactions
Chapter 64: Photosensitivity and Other Reactions to Sunlight
Section 9: Hematologic Alterations
Chapter 65: Interpreting Peripheral Blood Smears
Chapter 66: Anemia and Polycythemia
Chapter 67: Disorders of Granulocytes and Monocytes
Chapter 68: Primary and Secondary Hemophagocytic Lymphohistiocytosis
Chapter 69: Bleeding and Thrombosis
Chapter 70: Enlargement of Lymph Nodes and Spleen
Part 3: Pharmacology
Chapter 71: Principles of Clinical Pharmacology
Chapter 72: Pharmacogenomics
Part 4: Oncology and Hematology
Section 1: Neoplastic Disorders
Chapter 73: Approach to the Patient with Cancer
Chapter 74: Symptom Control in Patients with Cancer
Chapter 75: Prevention and Early Detection of Cancer
Chapter 76: Cancer Genetics
Chapter 77: Cancer Cell Biology
Chapter 78: Principles of Cancer Treatment
Chapter 79: Infections in Patients with Cancer
Chapter 80: Oncologic Emergencies
Chapter 81: Cancer of the Skin
Chapter 82: Head and Neck Cancer
Chapter 83: Neoplasms of the Lung
Chapter 84: Breast Cancer
Chapter 85: Upper Gastrointestinal Tract Cancers
Chapter 86: Colorectal Cancer
Chapter 87: Tumors of the Liver and Biliary Tree
Chapter 88: Pancreatic Cancer
Chapter 89: Gastrointestinal Neuroendocrine Tumors
Chapter 90: Renal Cell Carcinoma
Chapter 91: Cancer of the Bladder and Urinary Tract
Chapter 92: Benign and Malignant Diseases of the Prostate
Chapter 93: Testicular Cancer
Chapter 94: Gynecologic Malignancies
Chapter 95: Primary and Metastatic Tumors of the Nervous System
Chapter 96: Soft Tissue and Bone Sarcomas and Bone Metastases
Chapter 97: Carcinoma of Unknown Primary
Chapter 98: Paraneoplastic Syndromes: Endocrinologic/Hematologic
Chapter 99: Paraneoplastic Neurologic Syndromes and Autoimmune Encephalitis
Chapter 100: Cancer Survivorship and the Long-Term Impact of Cancer and Its Treatment
Section 2: Hematopoietic Disorders
Chapter 101: Hematopoietic Stem Cells
Chapter 102: Iron Deficiency and Other Acquired Anemias Due to Decreased Erythrocyte Production
Chapter 103: Disorders of Hemoglobin
Chapter 104: Megaloblastic Anemias
Chapter 105: Hemolytic Anemias
Chapter 106: Anemia Due to Acute Blood Loss
Chapter 107: Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
Chapter 108: Polycythemia Vera and Other Myeloproliferative Neoplasms
Chapter 109: Acute Myeloid Leukemia
Chapter 110: Chronic Myeloid Leukemia
Chapter 111: Acute Lymphoid Leukemia
Chapter 112: Chronic Lymphocytic Leukemia
Chapter 113: Non-Hodgkin’s Lymphoma
Chapter 114: Hodgkin’s Lymphoma
Chapter 115: Less Common Lymphoid and Myeloid Malignancies
Chapter 116: Plasma Cell Disorders
Chapter 117: Amyloidosis
Chapter 118: Transfusion Therapy and Biology
Chapter 119: Hematopoietic Cell Transplantation
Section 3: Disorders of Hemostasis
Updated! Chapter 120: Disorders of Platelets and Vessel Wall
Chapter 121: Coagulation Disorders
Chapter 122: Arterial and Venous Thrombosis
Chapter 123: Antiplatelet, Anticoagulant, and Fibrinolytic Drugs
Part 5: Infectious Diseases
Section 1: Basic Considerations in Infectious Diseases
Chapter 124: Approach to the Patient with an Infectious Disease
Chapter 125: Molecular Mechanisms of Microbial Pathogenesis
Chapter 126: Microbial Genomics and Infectious Disease
Chapter 127: Approach to the Acutely Ill Infected Febrile Patient
Chapter 128: Principles of Immunization
Chapter 129: Immunization Principles and Vaccine Use
Chapter 130: Health Recommendations for International Travel
Section 2: Clinical Syndromes: Community-Acquired Infections
Chapter 131: Pneumonia
Chapter 132: Lung Abscess
Chapter 133: Infective Endocarditis
Chapter 134: Infections of the Skin, Muscles, and Soft Tissues
Chapter 135: Infectious Arthritis
Chapter 136: Osteomyelitis
Chapter 137: Intraabdominal Infections and Abscesses
Chapter 138: Acute Infectious Diarrheal Diseases and Bacterial Food Poisoning
Chapter 139: Clostridioides difficile Infection, Including Pseudomembranous Colitis
Chapter 140: Urinary Tract Infections: Cystitis, Prostatitis, and Pyelonephritis
Chapter 141: Sexually Transmitted Infections: Overview and Clinical Approach
Chapter 142: Encephalitis
Chapter 143: Acute Meningitis
Chapter 144: Chronic and Recurrent Meningitis
Chapter 145: Brain Abscess and Empyema
Chapter 146: Infectious Complications of Bites
Section 3: Clinical Syndromes: Health Care–Associated Infections
Chapter 147: Infections Acquired in Health Care Facilities
Chapter 148: Infections in Transplant Recipients
Section 4: Therapy for Bacterial Diseases
Chapter 149: Treatment and Prophylaxis of Bacterial Infections
Chapter 150: Bacterial Resistance to Antimicrobial Agents
Section 5: Diseases Caused by Gram-Positive Bacteria
Chapter 151: Pneumococcal Infections
Chapter 152: Staphylococcal Infections
Chapter 153: Streptococcal Infections
Chapter 154: Enterococcal Infections
Chapter 155: Diphtheria and Other Corynebacterial Infections
Chapter 156: Listeria monocytogenes Infections
Chapter 157: Tetanus
Chapter 158: Botulism
Chapter 159: Gas Gangrene and Other Clostridial Infections
Section 6: Diseases Caused by Gram-Negative Bacteria
Chapter 160: Meningococcal Infections
Chapter 161: Gonococcal Infections
Chapter 162: Haemophilus and Moraxella Infections
Chapter 163: Infections Due to the HACEK Group and Miscellaneous Gram-Negative Bacteria
Chapter 164: Legionella Infections
Chapter 165: Pertussis and Other Bordetella Infections
Chapter 166: Diseases Caused by Gram-Negative Enteric Bacilli
Chapter 167: Acinetobacter Infections
Chapter 168: Helicobacter pylori Infections
Chapter 169: Infections Due to Campylobacter and Related Organisms
Chapter 170: Infections Due to Pseudomonas, Burkholderia, and Stenotrophomonas Species
Chapter 171: Salmonellosis
Chapter 172: Shigellosis
Chapter 173: Cholera and Other Vibrioses
Chapter 174: Brucellosis
Chapter 175: Tularemia
Chapter 176: Plague and Other Yersinia Infections
Chapter 177: Bartonella Infections, Including Cat-Scratch Disease
Chapter 178: Donovanosis
Section 7: Miscellaneous Bacterial Infections
Chapter 179: Nocardiosis
Chapter 180: Actinomycosis
Chapter 181: Whipple Disease
Chapter 182: Infections Due to Mixed Anaerobic Organisms
Section 8: Mycobacterial Diseases
Chapter 183: Tuberculosis
Chapter 184: Leprosy
Chapter 185: Nontuberculous Mycobacterial Infections
Chapter 186: Antimycobacterial Agents
Section 9: Spirochetal Diseases
Chapter 187: Syphilis
Chapter 188: Endemic Treponematoses
Chapter 189: Leptospirosis
Chapter 190: Relapsing Fever
Chapter 191: Lyme Borreliosis
Section 10: Diseases Caused by Rickettsiae, Mycoplasmas, and Chlamydiae
Chapter 192: Rickettsial Diseases
Chapter 193: Infections Due to Mycoplasmas
Chapter 194: Chlamydial Infections
Section 11: Viral Diseases: General Considerations
Chapter 195: Principles of Medical Virology
Chapter 196: Antiviral Chemotherapy, Excluding Antiretroviral Drugs
Section 12: Infections Due to DNA Viruses
Chapter 197: Herpes Simplex Virus Infections
Chapter 198: Varicella-Zoster Virus Infections
Chapter 199: Epstein-Barr Virus Infections, Including Infectious Mononucleosis
Chapter 200: Cytomegalovirus and Human Herpesvirus Types 6, 7, and 8
Chapter 201: Monkeypox, Molluscum Contagiosum, and Other Poxvirus Infections
Chapter 202: Parvovirus Infections
Chapter 203: Human Papillomavirus Infections
Section 13: Infections Due to DNA and RNA Respiratory Viruses
Chapter 204: Common Viral Respiratory Infections, Other Than COVID-19
Chapter 205: SARS-CoV-2 and COVID-19
Chapter 206: Influenza
Section 14: Infections Due to Human Immunodeficiency Virus and Other Human Retroviruses
Chapter 207: The Human Retroviruses
Chapter 208: Human Immunodeficiency Virus Disease: AIDS and Related Disorders
Section 15: Infections Due to RNA Viruses
Chapter 209: Viral Gastroenteritis
Chapter 210: Enterovirus, Parechovirus, and Reovirus Infections
Chapter 211: Measles (Rubeola)
Chapter 212: Rubella (German Measles)
Chapter 213: Mumps
Chapter 214: Rabies and Other Rhabdovirus Infections
Chapter 215: Arthropod-Borne and Rodent-Borne Virus Infections
Chapter 216: Filovirids: Orthoebolavirus and Orthomarburgvirus Infections
Section 16: Fungal Infections
Chapter 217: Pathogenesis, Diagnosis, and Treatment of Fungal Infections
Chapter 218: Histoplasmosis
Chapter 219: Coccidioidomycosis
Chapter 220: Blastomycosis
Chapter 221: Cryptococcosis
Chapter 222: Candidiasis
Chapter 223: Aspergillosis
Chapter 224: Mucormycosis
Chapter 225: Superficial Fungal Infections
Chapter 226: Uncommon Disseminated Fungal Infections
Chapter 227: Pneumocystis Infections
Section 17: Protozoal and Helminthic Infections: General Considerations
Chapter 228: Introduction to Parasitic Infections
Chapter 229: Agents Used to Treat Parasitic Infections
Section 18: Protozoal Infections
Chapter 230: Amebiasis and Infection with Free-Living Amebae
Chapter 231: Malaria
Chapter 232: Babesiosis
Chapter 233: Leishmaniasis
Chapter 234: Chagas Disease and African Trypanosomiasis
Chapter 235: Toxoplasma Infections
Chapter 236: Protozoal Intestinal Infections and Trichomoniasis
Section 19: Helminthic Infections
Chapter 237: Introduction to Helminthic Infections
Chapter 238: Trichinellosis and Other Tissue Nematode Infections
Chapter 239: Intestinal Nematode Infections
Chapter 240: Filarial and Related Infections
Updated! Chapter 241: Schistosomiasis and Other Trematode Infections
Chapter 242: Cestode Infections
Part 6: Disorders of the Cardiovascular System
Section 1: Introduction to Cardiovascular Disorders
Chapter 243: Approach to the Patient with Possible Cardiovascular Disease
Chapter 244: Basic Biology of the Cardiovascular System
Chapter 245: Epidemiology of Cardiovascular Disease
Section 2: Diagnosis of Cardiovascular Disorders
Chapter 246: Physical Examination of the Cardiovascular System
Chapter 247: Electrocardiography
Chapter 248: Noninvasive Cardiac Imaging: Echocardiography, Nuclear Cardiology, and Magnetic Resonance/Computed Tomography Imaging
Chapter 249: Diagnostic Cardiac Catheterization and Coronary Angiography
Section 3: Disorders of Rhythm
Chapter 250: Principles of Clinical Cardiac Electrophysiology
Updated! Chapter 251: The Bradyarrhythmias: Disorders of the Sinoatrial Node
Chapter 252: The Bradyarrhythmias: Disorders of the Atrioventricular Node
Chapter 253: Approach to Supraventricular Arrhythmias
Chapter 254: Physiologic and Nonphysiologic Sinus Rhythm
Chapter 255: Focal Atrial Tachycardia
Chapter 256: Paroxysmal Supraventricular Tachycardias
Chapter 257: Common Atrial Flutter and Macroreentrant and Multifocal Atrial Tachycardias
Chapter 258: Atrial Fibrillation
Chapter 259: Approach to Ventricular Arrhythmias
Chapter 260: Premature Ventricular Contractions, Nonsustained Ventricular Tachycardia, and Accelerated Idioventricular Rhythm
Chapter 261: Sustained Ventricular Tachycardia
Chapter 262: Polymorphic Ventricular Tachycardia and Ventricular Fibrillation
Chapter 263: Electrical Storm and Incessant Ventricular Tachycardia
Section 4: Disorders of the Heart, Muscles, Valves, and Pericardium
Chapter 264: Heart Failure: Pathophysiology and Diagnosis
Chapter 265: Heart Failure: Management
Chapter 266: Classification of Cardiomyopathy
Chapter 267: Genetic Cardiomyopathies
Chapter 268: Acute and Chronic Myocarditis
Chapter 269: Dilated Cardiomyopathies
Chapter 270: Amyloidosis and Other Restrictive Cardiomyopathies
Chapter 271: Cardiac Transplantation and Prolonged Assisted Circulation
Chapter 272: Aortic Stenosis
Chapter 273: Aortic Regurgitation
Chapter 274: Mitral Stenosis
Chapter 275: Mitral Regurgitation
Chapter 276: Mitral Valve Prolapse
Chapter 277: Tricuspid Valve Disease
Chapter 278: Pulmonic Valve Disease
Chapter 279: Multiple and Mixed Valvular Heart Disease
Chapter 280: Congenital Heart Disease in the Adult
Chapter 281: Pericardial Disease
Chapter 282: Atrial Myxoma and Other Cardiac Tumors
Chapter 283: Cardiac Trauma
Section 5: Coronary and Peripheral Vascular Disease
Chapter 284: Ischemic Heart Disease
Chapter 285: Non-ST-Segment Elevation Acute Coronary Syndrome (Non-ST-Segment Elevation Myocardial Infarction and Unstable Angina)
Chapter 286: ST-Segment Elevation Myocardial Infarction
Chapter 287: Percutaneous Coronary Interventions and Other Interventional Procedures
Chapter 288: Hypertension
Chapter 289: Renovascular Disease
Chapter 290: Deep-Venous Thrombosis and Pulmonary Thromboembolism
Chapter 291: Diseases of the Aorta
Chapter 292: Arterial Diseases of the Extremities
Chapter 293: Chronic Venous Disease and Lymphedema
Chapter 294: Pulmonary Hypertension
Part 7: Disorders of the Respiratory System
Section 1: Diagnosis of Respiratory Disorders
Chapter 295: Approach to the Patient with Disease of the Respiratory System
Updated! Chapter 296: Disturbances of Respiratory Function
Chapter 297: Diagnostic Procedures in Respiratory Disease
Section 2: Diseases of the Respiratory System
Chapter 298: Asthma
Chapter 299: Hypersensitivity Pneumonitis and Pulmonary Infiltrates with Eosinophilia
Chapter 300: Occupational and Environmental Lung Disease
Chapter 301: Bronchiectasis
Chapter 302: Cystic Fibrosis
Chapter 303: Chronic Obstructive Pulmonary Disease
Chapter 304: Interstitial Lung Disease
Chapter 305: Disorders of the Pleura
Chapter 306: Disorders of the Mediastinum
Chapter 307: Disorders of Ventilation
Chapter 308: Sleep Apnea
Chapter 309: Lung Transplantation
Chapter 310: Interventional Pulmonary Medicine
Part 8: Critical Care Medicine
Section 1: Respiratory Critical Care
Chapter 311: Approach to the Patient with Critical Illness
Chapter 312: Acute Respiratory Distress Syndrome
Chapter 313: Mechanical Ventilatory Support
Section 2: Shock and Cardiac Arrest
Chapter 314: Approach to the Patient with Shock
Chapter 315: Sepsis and Septic Shock
Chapter 316: Cardiogenic Shock and Pulmonary Edema
Chapter 317: Cardiovascular Collapse, Cardiac Arrest, and Sudden Cardiac Death
Section 3: Neurologic Critical Care
Chapter 318: Nervous System Disorders in Critical Care
Part 9: Disorders of the Kidney and Urinary Tract
Chapter 319: Approach to the Patient with Renal Disease or Urinary Tract Disease
Chapter 320: Cell Biology and Physiology of the Kidney
Chapter 321: Acute Kidney Injury
Chapter 322: Chronic Kidney Disease
Chapter 323: Dialysis in the Treatment of Kidney Failure
Chapter 324: Interventional Nephrology
Chapter 325: Kidney Transplantation
Chapter 326: Glomerular Diseases
Chapter 327: Polycystic Kidney Disease and Other Inherited Disorders of Tubule Growth and Development
Chapter 328: Tubulointerstitial Diseases of the Kidney
Chapter 329: Thrombotic Renovascular Disorders
Chapter 330: Nephrolithiasis
Chapter 331: Urinary Tract Obstruction
Part 10: Disorders of the Gastrointestinal System
Section 1: Disorders of the Alimentary Tract
Chapter 332: Approach to the Patient with Gastrointestinal Disease
Chapter 333: Gastrointestinal Endoscopy
Chapter 334: Diseases of the Esophagus
Chapter 335: Peptic Ulcer Disease and Related Disorders
Chapter 336: Disorders of Absorption
Chapter 337: Inflammatory Bowel Disease
Chapter 338: Irritable Bowel Syndrome
Chapter 339: Diverticular Disease and Common Anorectal Disorders
Chapter 340: Mesenteric Vascular Insufficiency
Chapter 341: Acute Intestinal Obstruction
Chapter 342: Acute Appendicitis and Peritonitis
Section 2: Nutrition
Chapter 343: Nutrient Requirements and Dietary Assessment
Chapter 344: Vitamin and Trace Mineral Deficiency and Excess
Chapter 345: Malnutrition and Nutritional Assessment
Chapter 346: Enteral and Parenteral Nutrition
Section 3: Liver and Biliary Tract Disease
Chapter 347: Approach to the Patient with Liver Disease
Updated! Chapter 348: Evaluation of Liver Function
Chapter 349: The Hyperbilirubinemias
Chapter 350: Acute Viral Hepatitis
Chapter 351: Toxic and Drug-Induced Hepatitis
Chapter 352: Chronic Hepatitis
Chapter 353: Alcohol-Associated Liver Disease
Chapter 354: Metabolic Dysfunction–Associated Steatotic Liver Disease and Steatohepatitis
Chapter 355: Cirrhosis and Its Complications
Chapter 356: Liver Transplantation
Chapter 357: Diseases of the Gallbladder and Bile Ducts
Section 4: Disorders of the Pancreas
Chapter 358: Approach to the Patient with Pancreatic Disease
Chapter 359: Acute and Chronic Pancreatitis
Part 11: Immune-Mediated, Inflammatory, and Rheumatologic Disorders
Section 1: The Immune System in Health and Disease
Chapter 360: Introduction to the Immune System
Chapter 361: Mechanisms of Regulation and Dysregulation of the Immune System
Chapter 362: Primary Immune Deficiency Diseases
Section 2: Disorders of Immune-Mediated Injury
Chapter 363: Urticaria, Angioedema, and Allergic Rhinitis
Chapter 364: Anaphylaxis
Chapter 365: Desensitization
Chapter 366: Mastocytosis
Chapter 367: Autoimmunity and Autoimmune Diseases
Chapter 368: Systemic Lupus Erythematosus
Chapter 369: Antiphospholipid Syndrome
Chapter 370: Rheumatoid Arthritis
Chapter 371: Acute Rheumatic Fever
Chapter 372: Systemic Sclerosis (Scleroderma) and Related Disorders
Chapter 373: Sjögren’s Disease
Chapter 374: Spondyloarthritis
Chapter 375: The Vasculitis Syndromes
Chapter 376: Behçet Syndrome
Chapter 377: Inflammatory Myopathies
Chapter 378: Relapsing Polychondritis
Chapter 379: Sarcoidosis
Chapter 380: IgG4-Related Disease
Chapter 381: Familial Mediterranean Fever and Other Hereditary Autoinflammatory Diseases
Section 3: Disorders of the Joints and Adjacent Tissues
Chapter 382: Approach to Articular and Musculoskeletal Disorders
Chapter 383: Osteoarthritis
Chapter 384: Gout and Other Crystal-Associated Arthropathies
Chapter 385: Fibromyalgia
Chapter 386: Arthritis Associated with Systemic Disease, and Other Arthritides
Chapter 387: Periarticular Disorders of the Extremities
Part 12: Endocrinology and Metabolism
Section 1: Endocrinology
Chapter 388: Approach to the Patient with Endocrine Disorders
Chapter 389: Mechanisms of Hormone Action
Chapter 390: Physiology of Anterior Pituitary Hormones
Chapter 391: Hypopituitarism
Chapter 392: Pituitary Tumor Syndromes
Chapter 393: Disorders of the Neurohypophysis
Chapter 394: Thyroid Gland Physiology and Testing
Chapter 395: Hypothyroidism
Chapter 396: Hyperthyroidism and Other Causes of Thyrotoxicosis
Chapter 397: Thyroid Nodular Disease and Thyroid Cancer
Chapter 398: Disorders of the Adrenal Cortex
Chapter 399: Pheochromocytoma
Chapter 400: Multiple Endocrine Neoplasia Syndromes
Chapter 401: Autoimmune Polyendocrine Syndromes
Section 2: Sex- and Gender-Based Medicine
Chapter 402: Sex Development
Chapter 403: Disorders of the Testes and Male Reproductive System
Chapter 404: Disorders of the Female Reproductive System
Chapter 405: Menstrual Disorders and Pelvic Pain
Chapter 406: Hirsutism
Chapter 407: Menopause and Postmenopausal Hormone Therapy
Chapter 408: Infertility and Contraception
Chapter 409: Sexual Dysfunction
Chapter 410: Women’s Health
Chapter 411: Men’s Health
Chapter 412: Lesbian, Gay, Bisexual, Transgender, Queer or Questioning, Intersex, Asexual, and More (LGBTQIA+) Health
Section 3: Obesity, Diabetes Mellitus, and Metabolic Syndrome
Chapter 413: Pathobiology of Obesity
Chapter 414: Evaluation and Management of Obesity
Chapter 415: Diabetes Mellitus: Diagnosis, Classification, and Pathophysiology
Chapter 416: Diabetes Mellitus: Management and Therapies
Chapter 417: Diabetes Mellitus: Complications
Chapter 418: Hypoglycemia
Chapter 419: Disorders of Lipoprotein Metabolism
Chapter 420: The Metabolic Syndrome
Section 4: Disorders of Bone and Mineral Metabolism
Chapter 421: Bone and Mineral Metabolism in Health and Disease
Chapter 422: Disorders of the Parathyroid Gland and Calcium Homeostasis
Chapter 423: Osteoporosis
Chapter 424: Paget’s Disease and Other Dysplasias of Bone
Section 5: Disorders of Intermediary Metabolism
Chapter 425: Heritable Disorders of Connective Tissue
Chapter 426: Hemochromatosis
Chapter 427: Wilson’s Disease
Chapter 428: The Porphyrias
Chapter 429: Lysosomal Storage Diseases
Chapter 430: Glycogen Storage Diseases and Other Inherited Disorders of Carbohydrate Metabolism
Chapter 431: Inherited Disorders of Amino Acid Metabolism in Adults
Chapter 432: Inherited Defects of Membrane Transport
Part 13: Neurologic Disorders
Section 1: Diagnosis of Neurologic Disorders
Chapter 433: Approach to the Patient with Neurologic Disease
Chapter 434: Neuroimaging in Neurologic Disorders
Chapter 435: Pathobiology of Neurologic Diseases
Section 2: Diseases of the Central Nervous System
Chapter 436: Seizures and Epilepsy
Updated! Chapter 437: Introduction to Cerebrovascular Diseases
Updated! Chapter 438: Ischemic Stroke
Chapter 439: Intracerebral Hemorrhage
Chapter 440: Subarachnoid Hemorrhage
Chapter 441: Migraine and Other Primary Headache Disorders
Chapter 442: Alzheimer’s Disease
Chapter 443: Frontotemporal Dementia
Chapter 444: Vascular Dementia
Chapter 445: Dementia with Lewy Bodies
Updated! Chapter 446: Parkinson’s Disease
Chapter 447: Tremor, Chorea, and Other Movement Disorders
Updated! Chapter 448: Amyotrophic Lateral Sclerosis and Other Motor Neuron Diseases
Chapter 449: Prion Diseases
Chapter 450: Ataxic Disorders
Chapter 451: Disorders of the Autonomic Nervous System
Chapter 452: Trigeminal Neuralgia, Bell’s Palsy, and Other Cranial Nerve Disorders
Chapter 453: Diseases of the Spinal Cord
Chapter 454: Concussion and Other Traumatic Brain Injuries
Chapter 455: Multiple Sclerosis
Chapter 456: Neuromyelitis Optica
Section 3: Nerve and Muscle Disorders
Chapter 457: Peripheral Neuropathy
Chapter 458: Guillain-Barré Syndrome and Other Immune-Mediated Neuropathies
Chapter 459: Myasthenia Gravis and Other Diseases of the Neuromuscular Junction
Chapter 460: Muscular Dystrophies and Other Muscle Diseases
Section 4: Syndromes Associated with Chronic Fatigue
Chapter 461: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Section 5: Psychiatric and Addiction Disorders
Chapter 462: Biology of Psychiatric Disorders
Chapter 463: Psychiatric Disorders
Chapter 464: Alcohol and Alcohol Use Disorders
Chapter 465: Nicotine Addiction
Chapter 466: Cannabis and Cannabis Use Disorder
Chapter 467: Opioid-Related Disorders
Chapter 468: Cocaine, Other Psychostimulants, and Hallucinogens
Part 14: Poisoning, Drug Overdose, and Envenomation
Chapter 469: Heavy Metal Poisoning
Chapter 470: Poisoning and Drug Overdose
Chapter 471: Disorders Caused by Venomous Snakebites and Marine Animal Exposures
Chapter 472: Ectoparasite Infestations and Arthropod Injuries
Part 15: Disorders Associated with Environmental Exposures
Chapter 473: Health Effects of Climate Change
Chapter 474: Climate Change and Infectious Disease
Chapter 475: Altitude Illness
Chapter 476: Hyperbaric and Diving Medicine
Chapter 477: Hypothermia and Peripheral Cold Injuries
Chapter 478: Heat-Related Illnesses
Part 16: Genes, the Environment, and Disease
Chapter 479: Principles of Human Genetics
Chapter 480: The Integration of Inherited Genetics into Clinical Practice
Chapter 481: Mitochondrial DNA and Heritable Traits and Diseases
Chapter 482: Telomere Disease
Chapter 483: Gene and Cell-Based Therapy in Clinical Medicine
Chapter 484: The Human Microbiome in Health and Disease
Part 17: Global Medicine
Chapter 485: Global Issues in Medicine
Chapter 486: Emerging and Re-Emerging Infectious Diseases
Chapter 487: Primary Care and Global Health
Part 18: Aging
Chapter 488: Biology of Aging
Chapter 489: Caring for the Geriatric Patient
Part 19: Consultative Medicine
Chapter 490: Approach to Medical Consultation
Chapter 491: Medical Disorders During Pregnancy
Chapter 492: Medical Evaluation of the Patient Undergoing Noncardiac Surgery
Part 20: Emerging Topics in Clinical Medicine
Chapter 493: Point-of-Care Ultrasound
Chapter 494: Improving Health and Health Care Using Behavioral Economics
Chapter 495: Complementary and Integrative Therapies and Practices
Chapter 496: Placebo and Nocebo Effects
Chapter 497: The Role of Epigenetics in Disease and Treatment
Chapter 498: The Role of Circadian Biology in Health and Disease
Chapter 499: Network Medicine and Multiomic Approaches to Health and Disease
Chapter 500: Emerging Neurotherapeutic Technologies
Chapter 501: Machine Learning and Augmented Intelligence in Clinical Medicine
Chapter 502: Metabolomics
Chapter 503: Circulating Nucleic Acids as Liquid Biopsies and Noninvasive Disease Biomarkers
Chapter 504: Protein Folding Disorders
Chapter 505: Novel Approaches to Diseases of Unknown Etiology
Part 21: Video Collection
Chapter V1: Video Library of Gait Disorders
Chapter V2: Primary Progressive Aphasia, Memory Loss, and Other Focal Cerebral Disorders
Chapter V3: Video Library of Neuro-Ophthalmology
Chapter V4: Examination of the Comatose Patient
Chapter V5: Video Atlas of Gastrointestinal Endoscopic Lesions
Chapter V6: The Neurologic Screening Exam
Chapter V7: Video Atlas of the Detailed Neurologic Examination
Chapter V8: Bedside Examination Tests in the Patient with Low Back Pain
Part 22: Supplementary Topics
Chapter S1: Fluid and Electrolyte Imbalances and Acid-Base Disturbances: Case Examples
Chapter S2: Cerebrospinal Fluid Disturbances: Case Examples
Chapter S3: Technique of Lumbar Puncture
Chapter S4: Microbial Bioterrorism
Chapter S5: Chemical Terrorism
Chapter S6: Radiation Terrorism
Chapter S7: Infections in War Veterans
Chapter S8: Health Care for Military Veterans
Chapter S9: Primary Immunodeficiencies Associated with (or Secondary to) Other Diseases
Chapter S10: The Clinical Laboratory in Modern Health Care
Chapter S11: Laboratory Diagnosis of Infectious Diseases
Chapter S12: Laboratory Diagnosis of Parasitic Infections
Chapter S13: Antithrombotic Therapy in Adult Patients
Part 23: Atlases
Chapter A1: Atlas of Rashes Associated with Fever
Chapter A2: Atlas of Blood Smears of Malaria and Babesiosis
Chapter A3: Atlas of Oral Manifestations of Disease
Chapter A4: Atlas of Urinary Sediments and Renal Biopsies
Chapter A5: Atlas of Skin Manifestations of Internal Disease
Chapter A6: Atlas of Hematology
Chapter A7: Atlas of Electrocardiography
Chapter A8: Atlas of Cardiac Arrhythmias
Chapter A9: Atlas of Noninvasive Imaging
Chapter A10: Atlas of Atherosclerosis
Chapter A11: Atlas of Percutaneous Revascularization and Adult Structural Heart Interventions
Chapter A12: Atlas of Chest Imaging
Chapter A13: Atlas of Liver Biopsies
Chapter A14: Atlas of the Vasculitic Syndromes
Chapter A15: Atlas of Clinical Manifestations of Endocrine and Metabolic Diseases
Chapter A16: Atlas of Neuroimaging
Part 24: Clinical Procedure Tutorials
Chapter CP1: Clinical Procedure Tutorial: Central Venous Catheter Placement
Chapter CP2: Clinical Procedure Tutorial: Thoracentesis
Chapter CP3: Clinical Procedure Tutorial: Abdominal Paracentesis
Chapter CP4: Clinical Procedure Tutorial: Endotracheal Intubation
Chapter CP5: Clinical Procedure Tutorial: Percutaneous Arterial Blood Gas Sampling
Chapter CP6: Clinical Procedure Tutorial: Lumbar Puncture
Chapter CP7: Clinical Procedures Tutorial: Phlebotomy
Chapter CP8: Clinical Procedures Tutorial: Insertion of Female Urethral Catheter
Chapter CP9: Clinical Procedures Tutorial: Insertion of Male Urethral Catheter
Chapter CP10: Clinical Procedures Tutorial: Fine Needle Aspiration of Breast Cyst
Chapter CP11: Clinical Procedures Tutorial: IV Insertion
Chapter CP12: Clinical Procedures Tutorial: Fine Needle Aspiration of Thyroid Nodules
Chapter CP13: Clinical Procedures Tutorial: Gynecologic Examination with Pap Smear
Chapter CP14: Clinical Procedures Tutorial: Knee Arthrocentesis
Chapter CP15: Clinical Procedures Tutorial: Pericardiocentesis
Chapter CP16: Clinical Procedures Tutorial: Bone Marrow Biopsy
Chapter CP17: Clinical Procedures Tutorial: Basic Suturing
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